Post by John A. Casler on Nov 4, 2008 13:09:32 GMT -8
Abstract: Low-Dose Creatine Combined with Protein
Originally posted to the SUPERTRAINING list by Jamie Carruthers
========================================
The below study concludes that a low-dose creatine combined with
protein supplementation increases lean tissue mass and results in a
greater relative increase in bench press but not leg press strength.
Low-dose creatine reduces muscle protein degradation and bone
resorption without increasing formaldehyde production.
Low-Dose Creatine Combined with Protein during Resistance Training in
Older Men.
Medicine & Science in Sports & Exercise. 40(9):1645-1652, September
2008.
Purpose: To determine whether low-dose creatine and protein
supplementation during resistance training (RT; 3 d[middle dot]wk-1;
10 wk) in older men (59-77 yr) is effective for improving strength
and muscle mass without producing potentially cytotoxic metabolites
(formaldehyde).
Methods: Older men were randomized (double-blind) to receive 0.1 g
[middle dot]kg-1 creatine + 0.3 g[middle dot]kg-1 protein (CP; n =
10), creatine (C; n = 13), or placebo (PLA; n = 12) on training days.
Measurements before and after RT included lean tissue mass (air-
displacement plethysmography), muscle thickness (ultrasound) of
elbow, knee, and ankle flexors and extensors, leg and bench press
strength, and urinary indicators of cytotoxicity (formaldehyde),
myofibrillar protein degradation [3-methylhistidine (3-MH)],and bone
resorption [cross-linked N-telopeptides of type I collagen (NTx)].
Results: Subjects in C and CP groups combined experienced greater
increases in body mass and total muscle thickness than PLA (P <
0.05). Subjects who received CP increased lean tissue mass (+5.6%)
more than C (+2.2%) or PLA (+1.0%; P < 0.05) and increased bench
press strength (+25%) to a greater extent than C and PLA combined
(+12.5%; P < 0.05). CP and C did not differ from PLA for changes in
formaldehyde production (+24% each). Subjects receiving creatine (C
and CP) experienced a decrease in 3-MH by 40% compared with an
increase of 29% for PLA (P < 0.05) and a reduction in NTx (-27%)
versus PLA (+13%; P = 0.05).
Conclusions: Low-dose creatine combined with protein supplementation
increases lean tissue mass and results in a greater relative increase
in bench press but not leg press strength. Low-dose creatine reduces
muscle protein degradation and bone resorption without increasing
formaldehyde production.
==================
Jamie Carruthers
Wakefield, UK
Originally posted to the SUPERTRAINING list by Jamie Carruthers
========================================
The below study concludes that a low-dose creatine combined with
protein supplementation increases lean tissue mass and results in a
greater relative increase in bench press but not leg press strength.
Low-dose creatine reduces muscle protein degradation and bone
resorption without increasing formaldehyde production.
Low-Dose Creatine Combined with Protein during Resistance Training in
Older Men.
Medicine & Science in Sports & Exercise. 40(9):1645-1652, September
2008.
Purpose: To determine whether low-dose creatine and protein
supplementation during resistance training (RT; 3 d[middle dot]wk-1;
10 wk) in older men (59-77 yr) is effective for improving strength
and muscle mass without producing potentially cytotoxic metabolites
(formaldehyde).
Methods: Older men were randomized (double-blind) to receive 0.1 g
[middle dot]kg-1 creatine + 0.3 g[middle dot]kg-1 protein (CP; n =
10), creatine (C; n = 13), or placebo (PLA; n = 12) on training days.
Measurements before and after RT included lean tissue mass (air-
displacement plethysmography), muscle thickness (ultrasound) of
elbow, knee, and ankle flexors and extensors, leg and bench press
strength, and urinary indicators of cytotoxicity (formaldehyde),
myofibrillar protein degradation [3-methylhistidine (3-MH)],and bone
resorption [cross-linked N-telopeptides of type I collagen (NTx)].
Results: Subjects in C and CP groups combined experienced greater
increases in body mass and total muscle thickness than PLA (P <
0.05). Subjects who received CP increased lean tissue mass (+5.6%)
more than C (+2.2%) or PLA (+1.0%; P < 0.05) and increased bench
press strength (+25%) to a greater extent than C and PLA combined
(+12.5%; P < 0.05). CP and C did not differ from PLA for changes in
formaldehyde production (+24% each). Subjects receiving creatine (C
and CP) experienced a decrease in 3-MH by 40% compared with an
increase of 29% for PLA (P < 0.05) and a reduction in NTx (-27%)
versus PLA (+13%; P = 0.05).
Conclusions: Low-dose creatine combined with protein supplementation
increases lean tissue mass and results in a greater relative increase
in bench press but not leg press strength. Low-dose creatine reduces
muscle protein degradation and bone resorption without increasing
formaldehyde production.
==================
Jamie Carruthers
Wakefield, UK