Jamie Carruthers has posted this URL to a very interesting finding on Metabolic Regulation and Type II Muscle Fibers.
(It is a little technical)
www.kwalshlab.org/izumiya2008.pdfHere is the abstract:
SUMMARYIn contrast to the well-established role of oxidative
muscle fibers in regulating whole-body metabolism,
little is known about the function of fast/glycolytic
muscle fibers in these processes. Here, we generated
a skeletal muscle-specific, conditional transgenic
mouse expressing a constitutively active form of
Akt1.
Transgene activation led to muscle hypertrophy
due to the growth of type IIb muscle fibers, which was
accompanied by an increase in strength. Akt1 transgene
induction in diet-induced obese mice led to reductions
in body weight and fat mass, resolution of
hepatic steatosis, and improved metabolic parameters.
Akt1-mediated skeletal muscle growth opposed
the effects of a high-fat/high-sucrose diet on transcript
expression patterns in the liver and increased
hepatic fatty acid oxidation and ketone body production.
Our findings indicate that an increase in fast/
glycolytic muscle mass can result in the regression
of obesity and metabolic improvement through its
ability to alter fatty acid oxidation in remote tissues.