Post by John A. Casler on Jan 26, 2009 13:13:35 GMT -8
This is from Jamie Carruthers as posted to SuperTraining
To visit SUPERTRAINING FORUM
health.groups.yahoo.com/group/Supertraining/?yguid=44276758
The below study found that essential amino acid ingestion shortly
following a bout of resistance exercise is beneficial in promoting
skeletal muscle growth and may be useful in counteracting muscle
wasting in a variety of conditions such as aging, cancer cachexia,
bedrest/physical inactivity, and perhaps during rehabilitation
following trauma or surgery.
Nutritional and Contractile Regulation of Human Skeletal Muscle
Protein Synthesis and mTORC1 Signaling
J Appl Physiol (January 15, 2009). doi:10.1152/japplphysiol.91397.2008
Micah J. Drummond1, Hans C. Dreyer2, Christopher S. Fry1, Erin L.
Glynn1, and Blake B. Rasmussen1*
In this review we discuss current findings in the human skeletal
muscle literature describing the acute influence of nutrients
(leucine-enriched essential amino acids in particular) and resistance
exercise on muscle protein synthesis and mTORC1 signaling. We show
that essential amino acids and an acute bout of resistance exercise
independently stimulate human skeletal muscle protein synthesis. It
also appears that ingestion of essential amino acids following
resistance exercise leads to an even larger increase in the rate of
muscle protein synthesis as compared to the independent effects of
nutrients or muscle contraction. Until recently the cellular
mechanisms responsible for controlling the rate of muscle protein
synthesis in humans were unknown.
In this review we highlight new studies in humans that have clearly
shown the mTORC1 signaling pathway is playing an important regulatory
role in controlling muscle protein synthesis in response to nutrients
and/or muscle contraction. We propose that essential amino acid
ingestion shortly following a bout of resistance exercise is
beneficial in promoting skeletal muscle growth and may be useful in
counteracting muscle wasting in a variety of conditions such as
aging, cancer cachexia, bedrest/physical inactivity, and perhaps
during rehabilitation following trauma or surgery.
===================
Jamie Carruthers
Wakefield, UK
To visit SUPERTRAINING FORUM
health.groups.yahoo.com/group/Supertraining/?yguid=44276758
The below study found that essential amino acid ingestion shortly
following a bout of resistance exercise is beneficial in promoting
skeletal muscle growth and may be useful in counteracting muscle
wasting in a variety of conditions such as aging, cancer cachexia,
bedrest/physical inactivity, and perhaps during rehabilitation
following trauma or surgery.
Nutritional and Contractile Regulation of Human Skeletal Muscle
Protein Synthesis and mTORC1 Signaling
J Appl Physiol (January 15, 2009). doi:10.1152/japplphysiol.91397.2008
Micah J. Drummond1, Hans C. Dreyer2, Christopher S. Fry1, Erin L.
Glynn1, and Blake B. Rasmussen1*
In this review we discuss current findings in the human skeletal
muscle literature describing the acute influence of nutrients
(leucine-enriched essential amino acids in particular) and resistance
exercise on muscle protein synthesis and mTORC1 signaling. We show
that essential amino acids and an acute bout of resistance exercise
independently stimulate human skeletal muscle protein synthesis. It
also appears that ingestion of essential amino acids following
resistance exercise leads to an even larger increase in the rate of
muscle protein synthesis as compared to the independent effects of
nutrients or muscle contraction. Until recently the cellular
mechanisms responsible for controlling the rate of muscle protein
synthesis in humans were unknown.
In this review we highlight new studies in humans that have clearly
shown the mTORC1 signaling pathway is playing an important regulatory
role in controlling muscle protein synthesis in response to nutrients
and/or muscle contraction. We propose that essential amino acid
ingestion shortly following a bout of resistance exercise is
beneficial in promoting skeletal muscle growth and may be useful in
counteracting muscle wasting in a variety of conditions such as
aging, cancer cachexia, bedrest/physical inactivity, and perhaps
during rehabilitation following trauma or surgery.
===================
Jamie Carruthers
Wakefield, UK