Post by John A. Casler on Jan 26, 2009 12:35:07 GMT -8
Jamie Carruthers posted on SUPERTRAINING
Aging, exercise and muscle protein metabolism.
J Appl Physiol. 2009 Jan 8. [Epub ahead of print] Links
Koopman R, van Loon LJ.
Aging is accompanied by a progressive loss of skeletal muscle mass
and strength, leading to the loss of functional capacity and an
increased risk of developing chronic metabolic disease. The age-
related loss of skeletal muscle mass is attributed to a disruption in
the regulation of skeletal muscle protein turnover, resulting in an
imbalance between muscle protein synthesis and degradation. As basal
(fasting) muscle protein synthesis rates do not seem to differ
substantially between the young and elderly, many research groups
have started to focus on the muscle protein synthetic response to the
main anabolic stimuli, i.e. food intake and physical activity. Recent
studies suggest that the muscle protein synthetic response to food
intake is blunted in the elderly. The latter is now believed to
represent a key factor responsible for the age-related decline in
skeletal muscle mass.
Physical activity and/or exercise stimulate post-exercise muscle
protein accretion in both the young and elderly. However, the latter
largely depends on the timed administration of amino acids and/or
protein prior to, during, and/or after exercise. Prolonged resistance
type exercise training represents an effective therapeutic strategy
to augment skeletal muscle mass and improve functional performance in
the elderly. The latter shows that the ability of the muscle protein
synthetic machinery to respond to anabolic stimuli is preserved up to
very old age.
Research is warranted to elucidate the interaction between nutrition,
exercise and the skeletal muscle adaptive response. The latter is
needed to define more effective strategies that will maximize the
therapeutic benefits of lifestyle intervention in the elderly. Key
words: sarcopenia, muscle hypertrophy, exercise training, nutrition,
amino acids.
Aging, exercise and muscle protein metabolism.
J Appl Physiol. 2009 Jan 8. [Epub ahead of print] Links
Koopman R, van Loon LJ.
Aging is accompanied by a progressive loss of skeletal muscle mass
and strength, leading to the loss of functional capacity and an
increased risk of developing chronic metabolic disease. The age-
related loss of skeletal muscle mass is attributed to a disruption in
the regulation of skeletal muscle protein turnover, resulting in an
imbalance between muscle protein synthesis and degradation. As basal
(fasting) muscle protein synthesis rates do not seem to differ
substantially between the young and elderly, many research groups
have started to focus on the muscle protein synthetic response to the
main anabolic stimuli, i.e. food intake and physical activity. Recent
studies suggest that the muscle protein synthetic response to food
intake is blunted in the elderly. The latter is now believed to
represent a key factor responsible for the age-related decline in
skeletal muscle mass.
Physical activity and/or exercise stimulate post-exercise muscle
protein accretion in both the young and elderly. However, the latter
largely depends on the timed administration of amino acids and/or
protein prior to, during, and/or after exercise. Prolonged resistance
type exercise training represents an effective therapeutic strategy
to augment skeletal muscle mass and improve functional performance in
the elderly. The latter shows that the ability of the muscle protein
synthetic machinery to respond to anabolic stimuli is preserved up to
very old age.
Research is warranted to elucidate the interaction between nutrition,
exercise and the skeletal muscle adaptive response. The latter is
needed to define more effective strategies that will maximize the
therapeutic benefits of lifestyle intervention in the elderly. Key
words: sarcopenia, muscle hypertrophy, exercise training, nutrition,
amino acids.